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Paint Tool Sai not recognizing tablet – possible solutions
Sai is an illustrator program that requires a tablet to work. It’s important to make sure you have your tablet plugged in before opening Sai or it won’t recognize the device. However, if you’re still having problems even after trying this fix, there’s a chance your operating system is responsible for the issue. Here are some solutions if you’re still having problems:
Try using your physical keyboard instead of the stylus. If you’re on Windows, try updating your operating system to the latest version. Try downloading a different art program as it’s possible one of them conflicts with Sai. Update and install the latest graphics card drivers. Remember, though, that if you’re already running a newer graphics card you may have to uninstall older chipsets entirely in order to install the latest one. Reinstall Sai.
If Sai still doesn’t recognize your tablet, you’ll have to uninstall it and get a new version from the Internet.

Paint Tool Sai not working on Windows 10
Users reported that one solution to the problem is to plug the mouse in and then unplug it. This process seems to work with most, though not all users. Another solution was to visit the Control Panel and change the mouse’s pointer to “pen.”
It appears that this problem is only for the users of Windows 10. The good news is that there are a lot of fixes out there, so it’s not a difficult problem to solve.
A third solution is to download and install AutoHotKey. This will fix your cursor up so it doesn’t happen again!
Several people have reported having problems with Paint Tool Sai on their Windows 10 machines. : “Paint tool sai not working on windows 10.”
What’s Happening?

How to fix Paint Tool Sai not opening
One user reported he had to uninstall everything and then start over. He also reported that uninstalling the driver for the pen might help, as well as using a different computer to load the program (especially if you’re using a laptop or tablet). It seems that whatever the cause, this problem is not going away. There is a solution, but it’s not easy. Here is what I’ve done:
1. On the computer where the file is stored, open Paint Tool Sai, click on “manage”. Under “tools” go to “windows”, and find the last 3 digits of your Windows version (e.g., Windows 8) in the first column. The last 3 digits are your Windows version, or un-pack number (or something like that). You should see a place to type a comment about that computer you’re using. Do so, then click save. I guess you can use this as a way to back up your settings too.
2. Close Sai, then open the file with Paint Tool Sai open (preferably NOT on the same computer).

Painting software not working – troubleshooting tips
Using an old driver or a version that’s not compatible with your OS can create problems. Use the latest drivers available for your Wacom tablet, and check for compatibility before you buy – in the event you want to upgrade your operating system at some point. Make sure your drivers are compatible with your OS as well.
There’s also the possibility that a driver was installed incorrectly, causing problems. Driver Rollback is a handy tool that can help you to uninstall problematic drivers – and then re-install them with ease. You should be able to get rid of any driver conflicts this way, and allow your tablet to work as it should.

How to get Paint Tool Sai to work on a Mac
See if your pen is recognized. If that doesn’t help, download an energy-conservation utility such as Power Manager. The tool will detect the problem and shut down power to the tablet. If you’re on a laptop, you can plug it in and turn the power off. This won’t help if you’re using a tablet, but it may solve the problem.
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3) [PICTURE OF POWER MANAGER]
See if your pen is recognized. If that doesn’t help, download an energy-conservation utility such as Power Manager. The tool will detect the problem and shut down power to the tablet. If you’re on a laptop, you can plug it in and turn the power off. This won’t help if you’re using a tablet, but it may solve the problem.
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[[SOLUTION]] 5)
6) [PICTURE OF ENERGY SAVING TOOL] [POST] 7) In Paint Tool Sai, click the gear icon to the upper-right of the screen and select “Settings.” On the left side of Paint Tool Sai’s settings, select “tablet.” Make sure that “Tablet Options” is selected on the right side. Click “Configure.”